Long Term Post-Treatment Follow-Up of Pituitary Tumours

Aim: To study the spectrum of Pituitary tumours, their presentation, treatment and compliance with follow-up. Study design: Mixed retrospective prospective Place duration study: Medicell Institute Diabetes, Endocrinology Metabolism Jinnah Postgraduate Medical Centre Karachi from 1st January 2012 to 31st July 2022. Methodology: One hundred seventy three cases pituitary were enrolled. Data regarding age, gender, disease, symptoms, mode administered follow-up instructions was retrieved. Results: The mean age 36.4±10.6 years. Female predominance seen in 97(56.1%). Of 136 married patients, subfertility 48(36.3%). Headache observed 164(94.8%) patients. Prolactinoma lead tumour comprising 76 (43.9%), followed by non-secretory tumours 47(27.2%), acromegaly 43(24.9%). Other rare disorders including Cushing’s craniopharyngioma gonadotropinoma also seen. Cabergoline prescribed (78.6%) cases. Transsphenoidal surgery (TSS) done 74(42.8%) Out 97 female 38(39.2%) had persistent amenorrhea post-treatment, while this data not available for 40(41.2%) these women, who lost difference between prolactin levels prior after (1390.048±2646.986 versus 116.360±163.369) found be statistically significant p<0.001). Similarly, IGF-1 significantly improved post indicating stability. Moreover, level FT4 post-treatment 1.64, reflecting adequate replacement. Conclusion: Majority patients improvement symptoms vision, headache sexual function. Failure attend stability, control excess hormone, hormone replacement a large number study. This requires careful consideration different strategies ensure better long term care tumours. Keywords: tumor, Prolactinoma, Craniopharyngioma, Gonadotropinoma, Acromegaly